With the latest release (10.1.15) we worked on optimizing the way variables are stored internally and were able to dramatically improve performance. Dick Lockey did some tests and writes that the latest version is 40 times faster than earlier versions!
If you’re working with scripts that create and process a large number of variables – say a script which reads and processes a large number of fields from a database – you’ll want to make sure you’re using the latest release, because your scripts will be noticeably faster with this version.